The optical sensing of chirality is widely used in many fields, such as pharmaceuticals, agriculture, food, and environmental materials.In this context, the color-based cascade amplification of chirality, coupled with chiral recognition for analytes, provides a low-cost and straightforward detection method that avoids the use of expensive and sophisticated click here instrumentation.However, the realization of chiral detection using this approach is still challenging because the construction of a three-dimensional optical recognition site is required to easily discern differences in chirality.Therefore, considerable efforts have been dedicated to developing a hierarchical approach based on molecular organization to provide colorimetric sensors for chirality detection.This review covers function-integrated molecular sensors with colorimetric responsive sites based on absorption, fluorescence, and aggregation-induced emission enabled by molecular organization.
In line with the hierarchical trailmaster challenger 200x approach, data-driven chemometrics is a useful method for quantitative and accurate chiral pattern recognition.Finally, colorimetric nanomaterials are discussed, focusing on sensing platforms using noble-metal nanoparticles, carbon dots, and photonic crystal gels.